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Male and estradiol
Very little, and it'll be out of his system within a few weeks. Unless he no longer has his gonads, the testosterone produced by them will by far exceed the estrogens, and thus there will be absolutely no difference, except for a slightly higher risk of blood clotting while he was on them. By now, assuming he's stopped on August 3 or earlier, it's totally out of his system.

Males also have estrogens, some with higher concentrations than others. But the testosterone really lords over it and prevents it from doing anything unwanted unless a person uses what's called an anti-androgen, or testosterone blocker, such as spironolactone.

And 2 weeks really isn't enough for anything at all even if he used both, it takes over a year for anything permanent at that age. So don't worry.

Though I must say I'm curious as to how this came to be.

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A penny found is penny to clutter up your purse.

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Estrace questions
Here's my situation:

I'm a 17 year old transgender female who is currently 5 days on Estrace (4mg daily) for Hormone Replacement Therapy (HRT). I am also on Spironolactone (200mg daily) for an anti-androgen.

I'd like to know of any substances I should avoid that might decrease the effectiveness of the said drugs, especially information regarding the actual effects of alcohol and caffeine.

Alcohol is bad for obvious reasons, since this hormone regimen is an awful stress on my liver, but does it actually alter in any way the effectiveness of the drug? I have also heard rumors that caffeine can slow the effects of it, but the only evidence I have found states that caffeine actually RAISES ones estrogen levels substantially (500mg caffeine daily, or about 5 cups, yields 70% higher estrogen levels in the average person, regardless of gender.)

I've also searched for any form of base website on Estrace, but have turned up empty-handed. Do they have a website that describes what to do and what to avoid once on a regimen?

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A penny found is penny to clutter up your purse.

Read More in our Estradiol (Estrace; Climara; Estraderm) Forum Forum