Silver Sulfadiazine (Topical)

Brand name(s): Silvadene

Before Using This Medicine

In deciding to use a medicine, the risks of using the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For silver sulfadiazine, the following should be considered:

Allergies-Tell your doctor if you have ever had any unusual or allergic reaction to silver sulfadiazine or to any of the following medicines:

• Acetazolamide (e.g., Diamox)
• Antidiabetics, oral (diabetes medicine you take by mouth)
• Dichlorphenamide (e.g., Daranide)
• Furosemide (e.g., Lasix)
• Methazolamide (e.g., Neptazane)
• Sulfonamides, other (sulfa medicine)
• Thiazide diuretics (water pills)

Also tell your health care professional if you are allergic to any other substances, such as preservatives or dyes.

Pregnancy-Studies have not been done in humans. However, sulfa medicines may increase the chance of liver problems in newborn infants. Silver sulfadiazine has not been shown to cause birth defects or other problems in studies in rabbits treated with 3 to 10 times the usual amount of silver sulfadiazine.

Breast-feeding-It is not known whether silver sulfadiazine applied to the skin and/or burns passes into the breast milk. However, silver sulfadiazine may be absorbed into the body when used on skin and/or burns. Sulfa medicines given by mouth do pass into the breast milk. They may cause liver problems, anemia (iron-poor blood), and other unwanted effects in nursing babies, especially those with glucose-6-phosphate dehydrogenase deficiency (lack of G6PD enzyme). Therefore, caution is recommended when using this medicine in nursing women.

Children-Use is not recommended in premature or newborn infants up to 2 months of age. Sulfa medicines may cause liver problems in these infants. Although there is no specific information comparing use of silver sulfadiazine in older infants and children with use in other age groups, this medicine is not expected to cause different side effects or problems in older infants and children than it does in adults.

Older adults-Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults or if they cause different side effects or problems in older people. There is no specific information comparing use of silver sulfadiazine in the elderly with use in other age groups.

Other medicines-Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking silver sulfadiazine, it is especially important that your health care professional know if you are taking any of the following:

• Cimetidine-May increase the risk of leukopenia (low white blood cell counts)

• Collagenase (e.g., Santyl) or
• Papain (e.g., Panafil) or
• Sutilains (e.g., Travase)-Silver sulfadiazine may prevent these enzymes from working properly

Other medical problems-The presence of other medical problems may affect the use of silver sulfadiazine. Make sure you tell your doctor if you have any other medical problems, especially:

• Blood problems or
• Glucose-6-phosphate dehydrogenase deficiency (lack of G6PD enzyme)-Use of this medicine may cause blood problems or make them worse

• Kidney disease or
• Liver disease-In persons with these conditions, use may result in higher blood levels of this medicine; a smaller dose may be needed

• Porphyria-Use of this medicine may result in a severe attack of porphyria

Last Revised: 03/17/2000