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Ondansetron (Systemic)

Brand name(s): Zofran

Order From TotalMeds.com

Before Using This Medicine

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For ondansetron, the following should be considered:

Allergies-Tell your doctor if you have ever had any unusual or allergic reaction to ondansetron. Also tell your health care professional if you are allergic to any other substances, such as foods, preservatives, or dyes.

Pregnancy-Ondansetron has not been studied in pregnant women. However, this medicine has not been shown to cause birth defects or other problems in animal studies. Before taking this medicine, make sure your doctor knows if you are pregnant or if you may become pregnant.

Breast-feeding-It is not known whether ondansetron passes into the breast milk. Although most medicines pass into breast milk in small amounts, many of them may be used safely while breast-feeding. Mothers who are taking this medicine and who wish to breast-feed should discuss this with their doctor.

Children-This medicine has been tested in a limited number of children with cancer 6 months of age or older and after surgery in children 1 month to 12 years of age. In effective doses, the medicine has not been shown to cause different side effects or problems than it does in adults.

Older adults-This medicine has been tested in a limited number of cancer patients 65 years of age or older and has not been shown to cause different side effects or problems in older people than it does in younger adults.

Other medicines-Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your health care professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Other medical problems-The presence of other medical problems may affect the use of ondansetron. Make sure you tell your doctor if you have any other medical problems, especially:
  • Abdominal surgery-Use of ondansetron may cover up stomach problems
  • Allergy to selective 5-HT3 receptor antagonists (alosetron [e.g., Lotronex], dolasetron [e.g., Anzemet], granisetron [e.g., Kytril], palonosetron [e.g., Aloxi])- If you are allergic to one of these, you may be allergic to ondansetron because they are in the same group of medicines.
  • Liver disease-Patients with liver disease may have an increased chance of side effects
  • Phenylketonuria (PKU)-The oral disintegrating tablets may contain aspartame, which can make your condition worse.

Last Revised: 04/12/2005

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