Octreotide (Systemic)

Brand name(s): Sandostatin

Proper Use of This Medicine

To control the symptoms of your medical problem, this medicine must be taken as ordered by your doctor. Make sure that you understand exactly how to take this medicine.

Octreotide is packaged in a kit containing an ampul opener, alcohol swabs, ampuls of the medicine, and, in some kits, a vial of diluent to mix with the medicine. Directions on how to prepare and inject the medicine are in the package. Read the directions carefully and ask your health care professional for additional explanation, if necessary.

It is important to follow any instructions from your doctor about the careful selection and rotation of injection sites on your body. This will help to prevent skin problems, such as irritation.

Some patients may feel pain, stinging, tingling, or burning sensations at the place where they inject the medicine. These sensations usually last only a few moments and may be eased by rubbing the spot after the injection. Injecting the medicine after it has been warmed to room temperature rather than cold from the refrigerator may reduce the discomfort. The medicine should be taken from the refrigerator 20 to 60 minutes before it is to be used. However, do not use heat to warm it faster because heat can destroy the medicine.

Put used needles and syringes in a puncture-resistant disposable container or dispose of them as directed by your health care professional. Do not reuse needles and syringes .

Dosing-

The dose of octreotide will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of octreotide. If your dose is different, do not change it unless your doctor tells you to do so.

• For long-acting injection dosage form:
  • For treating the severe diarrhea that occurs with certain types of intestinal tumors:
    • Adults and teenagers-At first, 20 milligrams (mg) injected into the gluteal muscle once every four weeks for two months. Then, the dose will be adjusted by your doctor, based on your response to the medicine.
    • Children-Use and dose must be determined by your doctor.
  • For treating acromegaly:
    • Adults-At first, 20 mg injected into the gluteal muscle once every four weeks for three months. Then, the dose will be adjusted by your doctor, based on your response to the medicine.
• For short-acting injection dosage form:
  • For treating the severe diarrhea that occurs with certain types of intestinal tumors:
    • Adults and teenagers-At first, 50 micrograms (mcg) injected under the skin two or three times a day. Then, the dose is slowly increased. Some people may need doses as high as 600 mcg a day for the first two weeks. Thereafter, the dose is usually between 50 and 1500 mcg per day.
    • Children-The dose is based on body weight and must be determined by your doctor. The usual dose is 1 to 10 mcg per kilogram (kg) (0.45 to 4.5 mcg per pound) of body weight a day, injected under the skin.
  • For treating acromegaly:
    • Adults-At first, 50 mcg injected under the skin or into a vein three times a day. Then, the dose is slowly increased to 100 to 200 mcg three times a day. Higher doses may be needed, as determined by your doctor.

Missed dose-

If you miss a dose of the long-acting form of this medicine, contact your doctor.

If you miss a dose of the short-acting form of this medicine, use it as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses. Although you will not be harmed by forgetting a dose, the symptoms that you are trying to control (for example, diarrhea) may reappear. To be able to control your symptoms, your doses should be evenly spaced over a period of 24 hours. If you have any questions about this, check with your health care professional.

Storage-

To store this medicine:

• Keep out of the reach of children.
• Store the ampuls of octreotide in the refrigerator until they are to be used. Ampuls of the short-acting form of octreotide may be kept at room temperature for 14 days when they are protected from light. If the ampuls are not protected from light, problems with the solution can develop much sooner.
• Do not keep outdated medicine or medicine no longer needed. Be sure that any discarded medicine and syringes are out of the reach of children.

Last Revised: 01/07/2003

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