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Estrace questions
Here's my situation:

I'm a 17 year old transgender female who is currently 5 days on Estrace (4mg daily) for Hormone Replacement Therapy (HRT). I am also on Spironolactone (200mg daily) for an anti-androgen.

I'd like to know of any substances I should avoid that might decrease the effectiveness of the said drugs, especially information regarding the actual effects of alcohol and caffeine.

Alcohol is bad for obvious reasons, since this hormone regimen is an awful stress on my liver, but does it actually alter in any way the effectiveness of the drug? I have also heard rumors that caffeine can slow the effects of it, but the only evidence I have found states that caffeine actually RAISES ones estrogen levels substantially (500mg caffeine daily, or about 5 cups, yields 70% higher estrogen levels in the average person, regardless of gender.)

I've also searched for any form of base website on Estrace, but have turned up empty-handed. Do they have a website that describes what to do and what to avoid once on a regimen?

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Risperidone
Two months ago I experienced an acute psychotic breakdown, induced by LSD, alcohol and cannabis use a week before the incident. It was incredibly visceral and at the height of it I couldn't walk, talk, eat or know what on earth was going on, I completely lost touch with reality and my identity.
I was hospitalised and prescribed 1 mg of Risperidone per day, and made a quick recovery. I am now off the drug. The drug did have some side effects, though they were quite subtle as the dose was relatively small.

The most annoying of the side effects was increased anxiety, which sometimes turned into paranoia, I would get quite worried about aspects of my health, I convinced myself after reading various medical and biology textbooks that I had some form of drug induced parkinsonis, pre-symptomal tuberculosis, joint problems. Looking back on it I was quite silly, but I couldn't help it, I was feeling so much more worried than I normally did. I did also have occasional periods of temporary paranoia, ie is this tapping sound really there? Is it somebody in the house?

I also found it harder to get to sleep, I would wake up quite a bit in the middle of the night and found it harder to get into a comfortable position. I would alternate between feeling cold and hot, I sweated quite a lot in bed as well. I would spend hours in a strange psuedo-sleep state, where I was starting to drift off, but not enough to lose consciousness, it was a wierd limbo-state between being awake and being asleep. When I did sleep I experienced vivid dream, where I saw some very vivid images, some of which are still very clear and crisp now, I think I might attempt to draw them someday.

Increased tiredness/loss of concentration was another thing I experienced whilst on the medication, when I took the medication I started feeling somewhat heavy and lethargic. I found that when reading or doing maths excercises that I would start off quite well, but after 5-10 minutes I would slow down and get distracted. I would also get tired quickly after starting physical activity such as riding a bike. I would also get very depressed at times.

Sometimes I would find it harder to focus on objects, especially in the dark, occasionally I got mildly blurred vision. These effects became less marked as time passed. On a sidenote I can also mention that I experienced mild visual flashbacks whilst being on the medication, I have been off the medication for 3 days now and they are becoming less noticable and frequent, as of now I have seen none, I am told that risperidone exacberates the occurence of flashbacks.

One more thing I noticed is that sometimes I would feel a shock, I would hear my heart beating and I would start hyperventilating, I would feel odd in the chest area, like my heart was beating in an odd way or something. This happened just a few times, about two hours after I took the medication.

As said, its been three days since I've been off the medication, and I am already starting to feel better and all the side-effects I have written about have greatly subsided or disappeared all-together. I feel very lucky and grateful that I have recovered something I caused myself because of my own foolishness.
I hope this is helpful to anybody curious about the medication.
Read More in our Risperidone (Risperdal) Forum