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Lopinavir and Ritonavir
Kaletra Logo
Brand name(s): Kaletra
What special precautions should I follow?
Before taking lopinavir and ritonavir,
- tell your doctor and pharmacist if you are allergic to lopinavir, ritonavir (Norvir), or any other medications.
- do not take lopinavir and ritonavir if you are taking astemizole (Hismanal), cisapride (Propulsid), dihydroergotamine (D.H.E. 45, Migranal), ergonovine (Ergotrate Maleate), ergotamine (Cafatine, Cafergot, Cafetrate, others), flecainide (Tambocor), methylergonovine (Methergine), midazolam (Versed), pimozide (Orap), propafenone (Rythmol), terfenadine (Seldane), or triazolam (Halcion).
- tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, and nutritional supplements you are taking. Be sure to mention any of the following: anticoagulants (''blood thinners'') such as warfarin (Coumadin); antifungals such as itraconazole (Sporanox) and ketoconazole (Nizoral); atovaquone (Mepron); calcium-channel blockers such as felodipine (Plendil), nicardipine (Cardene), and nifedipine (Adalat, Procardia); cholesterol-lowering medications such as atorvastatin (Lipitor), lovastatin (Mevacor), and simvastatin (Zocor); clarithromycin (Biaxin); disulfiram (Antabuse); medications for irregular heartbeats such as amiodarone (Cordarone, Pacerone), bepridil (Vascor), and quinidine (Quinidex); medications for seizures such as carbamazepine (Tegretol), phenobarbital (Luminal, Solfoton), and phenytoin (Dilantin); medications that suppress the immune system such as cyclosporine (Neoral, Sandimmune), Rapamune (sirolimus), and tacrolimus (Prograf); methadone (Dolophine); metronidazole (Flagyl); oral steroids such as dexamethasone (Decadron, Dexone); other antiviral medications such as amprenavir (Agenerase), delavirdine (Rescriptor), efavirenz (Sustiva), indinavir (Crixivan), nevirapine (Viramune), ritonavir (Norvir), and saquinavir (Fortovase, Invirase); rifabutin (Mycobutin); rifampin (Rifadin, Rimactane); and sildenafil (Viagra). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
- if you are taking didanosine, take it 1 hour before or 2 hours after lopinavir and ritonavir.
- tell your doctor what herbal products you are taking, especially products containing St. John's wort.
- tell your doctor if you have ever had pancreas disease and if you have or have ever had diabetes, liver disease, or hemophilia.
- you should know that lopinavir and ritonavir may decrease the effectiveness of oral contraceptives (birth control pills). Talk to your doctor about using another form of birth control.
- tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking lopinavir and ritonavir, call your doctor. You should not breast-feed while taking lopinavir and ritonavir.
- you should know that lopinavir and ritonavir solution contains alcohol and may make you drowsy. Do not drive a car or operate machinery until you know how this medication affects you.
- remember that alcohol can add to the drowsiness caused by this medication.
- you should be aware that your body fat may increase or move to different areas of your body, such as your breasts and your upper back.
Last Revised: 04/01/2003
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