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Glyburide and Metformin (Systemic)

Brand name(s): Glucovance

Order From TotalMeds.com

Proper Use of This Medicine

Follow carefully the special meal plan your doctor gave you. This is the most important part of controlling your condition, and is necessary if the medicine is to work properly. Also, exercise regularly and test for sugar in your blood or urine as directed.

Glyburide and metformin combination should be taken with meals to help reduce the gastrointestinal side effects that may occur during the first few weeks of treatment.

Dosing-

The dose of the glyburide and metformin combination will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of glyburide and metformin. If your dose is different, do not change it unless your doctor tells you to do so.

  • For oral dosage form (tablets):
    • For type 2 diabetes:
      • For first-time treatment:
        • Adults: At first, 1.25 milligrams (mg) of glyburide and 250 mg of metformin one or two times a day with meals. Then, your doctor may increase your dose a little at a time every two weeks until your blood sugar is controlled.
        • Children: Use and dose must be determined by your doctor.
      • For patients previously treated with a sulfonylurea antidiabetic agent and/or metformin:
        • Adults: At first, 2.5 mg of glyburide and 500 mg of metformin or 5 mg of glyburide and 500 mg of metformin two times a day, with the morning and evening meals. Then, your doctor may increase your dose a little at a time until your blood sugar is controlled.
        • Children: Use and dose must be determined by your doctor.

Storage-

To store this medicine:

  • Keep out of the reach of children.
  • Do not store in the bathroom, near the kitchen sink, or in other damp places. Heat or moisture may cause the medicine to break down.
  • Keep the medicine from freezing. Do not refrigerate.
  • Do not keep outdated medicine or medicine no longer needed. Ask your health care professional how you should dispose of any medicine you do not use. Be sure that any discarded medicine is out of the reach of children.

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Last Topics in Meds-Help.com Forums

Glyburide/Metform 2.5 Twice a day
My understanding is that Glyburide is used to flog the Pancreas to make it produce more insulin. However, from what I've heard (you should research it yourself) is that the bodies own immune system turns on the pancreas and distroys it in type 1 diabetes. With no pancreas to flog, I cannot see why your father would have been on Glyburide. But there may be other causes and results to type 1 diabetes. Metformin on the other hand works at getting cells to utilize the insulin that already exists in the body in type 2 or insulin resistant diabetes.. I've included a link to Dr. Koop.com on Lactic Acidosis -
http://www.drkoop.com/ency/93/000391.html
web md dot com also has some info but not much..

--------------------
Dave

Read More in our Glyburide (Diabeta, Glynase, Micronase) Forum Forum

Glyburide Symptoms
I am a new Glyburide user. Took my first 5mg pill 7 hours ago. Woke up this morning with chest pain, especially with deep breathing. Is this a common symptom for a new user. Blood sugar is 101.
Read More in our Glyburide (Diabeta, Glynase, Micronase) Forum Forum

weight gain with Glyburide
I am unhappy with the weight gain since starting Glyburide approx. 5 years ago. Recently my doctor recommended that I try going without G. for a while and see what happens. After only 2.5 weeks and no other changes in diet or exercise I have lost 4 lbs. That makes me happy BUT the other side of the story is that my blood sugers are much higher which is NOT good. Has anyone tried something else that works like G. but without the weight problem?

--------------------
Always leave a place a little better than you found it.

Read More in our Glyburide (Diabeta, Glynase, Micronase) Forum Forum

weight gain with Glyburide
I have not started taking Glyburide yet. The doctors have changed my medications so much it is hard to remember what I have taken. I don't know anything about glyburide and was hoping to find more info here. I am worried about the weight gain because I have gained a total of 63 pounds with the different medications they have put me on. Not on a specific diet because I can't keep anything down thanks to the glucophage I was taking. If you know of any other meds better than this one that do not cause weight gain please let me know.
Read More in our Glyburide (Diabeta, Glynase, Micronase) Forum Forum

Glyburide not lowering blood sugar
Blyburide has controlled my blood sugar for several years now. I recently had to increase my dosage to 2.5 MG prior to each meal (three times daily) and it doesn't lower my blood sugar. Could I have developed a tolerance for Glyburide to the point that it doesn't affect my blood sugar? I recently had stones removed from my prostate and changed blood pressure medication. [Frown]
Read More in our Glyburide (Diabeta, Glynase, Micronase) Forum Forum

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