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Medroxyprogesterone is used to treat abnormal uterine bleeding, promote menstrual cycles, and to treat symptoms of the menopause. Progestins are responsible for changes in the mucus and inner lining of the uterus (endometrium) during the second half (secretory phase) of the menstrual cycle. Progestins prepare the endometrium for implantation of the embryo, and once an embryo implants in the endometrium, i.e., pregnancy occurs, progestins help maintain the pregnancy. At high doses, progestins also prevent ovulation (release of the egg from the ovary). Progestins were first isolated in 1933, and progesterone itself was synthesized in the 1940s.
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