Enfuvirtide Injection

FuzeonŽ
Other name(s): T-20; Pentafuside Logo

Brand name(s): FuzeonŽ
Other name(s): T-20; Pentafuside

How should this medicine be used?

Enfuvirtide comes as a powder to be mixed with sterile water and injected subcutaneously (under the skin). It is usually injected twice a day. To help you remember to inject enfuvirtide, inject it at about the same times each day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Use enfuvirtide exactly as directed. Do not use more or less of it or use it more often than prescribed by your doctor.

Enfuvirtide controls HIV but does not cure it. Continue to use enfuvirtide even if you feel well. Do not stop using enfuvirtide without talking to your doctor. If you miss doses or stop using enfuvirtide, your condition may become more difficult to treat.

You will receive your first dose of enfuvirtide in your doctor's office. After that, you can inject enfuvirtide yourself or have a friend or relative perform the injections. Your doctor will train the person who will be injecting the medication, and will test him to be sure he can give the injection correctly. Be sure that you and the person who will be giving the injections read the manufacturer's information for the patient that comes with enfuvirtide before you use it for the first time at home.

You can inject enfuvirtide anywhere on your thighs, stomach, or upper arms except your navel (belly button) and any area directly under a belt or waistband. To reduce the chances of soreness or redness, choose a different area for each injection. Use your fingertips to check your chosen area for hard bumps under the skin. Never inject enfuvirtide into any skin that has a scar, bruise, mole, or reaction to a previous injection of enfuvirtide.

Never reuse needles, syringes, vials of enfuvirtide, or vials of sterile water. Dispose of used needles and syringes in a puncture-resistant container. You can dispose of used alcohol pads and vials in the trash, but if you see blood on an alcohol pad, put it in the puncture-resistant container. Talk to your doctor or pharmacist about how to dispose of the puncture-resistant container.

Before preparing an enfuvirtide dose, wash your hands with soap and water. After you wash your hands, do not touch anything except the medication, supplies, and the area where you will inject the medication.

To prepare and inject enfuvirtide, follow these steps:

• Open the packages of one 3-mL (large) syringe and one 1-mL (small) syringe and remove the caps from one vial of enfuvirtide and one vial of sterile water. Throw away the packages and caps.
• Wipe each vial top with a new alcohol pad and allow to air dry. Be careful not to touch the tops of the vials after you clean them. If you do touch the tops, clean them again with a new alcohol pad.
• Gently tap the enfuvirtide vial to loosen the powder.
• Slowly pull back the plunger of the 3-mL syringe to the 1.1 mL mark. Be careful not to push the plunger past the 0.2 mL mark.
• Insert the needle into the sterile water vial and slowly inject the air into the vial. Do not remove the needle from the vial.
• Turn the vial upside down and check to be sure the needle tip is below the surface of the water. Slowly pull the plunger back to the 1.1 mL mark. The syringe should fill with 1.1 mL of water.
• Check the syringe for air bubbles. Gently tap the syringe and push and pull the plunger to remove air bubbles. You may need to pull the plunger back further to get the full amount of water.
• When you are certain that the syringe contains 1.1 mL of water and no air bubbles, carefully remove the needle from the vial.
• Insert the needle of the syringe you have just filled into the enfuvirtide vial at an angle.
• Push down the plunger slowly to inject the sterile water into the vial. The water should drip down the side of the vial onto the powder.
• Remove the needle from the vial and push the plunger all the way down with the tip of your thumb until you hear a snap. The needle will spring back into the syringe. Dispose of the syringe properly.
• Tap the enfuvirtide vial gently with your fingertip for 10 seconds. Then roll it between your hands for a short while, but do not shake it. Be sure there is no powder stuck to the walls of the vial.
• If you are not ready to inject the medication, you may write the date and time you mixed the medication on the vial and place the vial in the refrigerator at this point. You may store the mixed medication in the refrigerator for up to 24 hours. Allow the medication to warm to room temperature and be sure that it is clear before you use it.
• If you are ready to inject the medication, leave the vial upright on a flat surface and wait for the powder to dissolve. This may take up to 45 minutes. You will know the powder has dissolved when the vial is clear and not foamy. If there are small bubbles in the vial, tap the vial gently until they disappear. If there are particles in the vial, do not use the vial, and call the pharmacy that provided it.
• Rub a new alcohol pad over the place where you will inject enfuvirtide using pressure and a circular motion. Allow the area to air dry.
• Clean the vial top again with a new alcohol pad and allow it to air dry.
• Pull back the plunger on the 1-mL syringe to the 1-mL mark. Be careful not to push it past the 0.05 mL mark.
• Insert the needle into the enfuvirtide vial and slowly push down the plunger to inject air. Do not remove the needle from the vial.
• Turn the vial upside down and check to be sure the needle is below the surface of the liquid. Slowly pull back the plunger to the 1 mL mark. The syringe should fill with 1mL of liquid.
• Check the syringe for air bubbles. Gently tap the syringe and push and pull the plunger to remove air bubbles. You may need to pull the plunger back further to get the full amount of liquid.
• When you are certain that the syringe contains 1 mL of liquid and no air bubbles, carefully remove the needle and syringe from the vial.
• Pinch and hold a fold of skin around the cleaned area where you will inject enfuvirtide. With your other hand, hold the needle like a pencil at a 45 degree angle.
• Push the needle into your skin until 3/4 of the needle is under the skin.
• Use your thumb to push the plunger down as far as it will go. The needle should pull out of your skin and spring back into the syringe when you do this. If it does not, pull the needle out of your skin and push the plunger down until the needle goes into the syringe.
• Dispose of the needle properly and cover the spot where you injected enfuvirtide with a small bandage if you see any blood or medication on your skin.

Last Revised: 10/01/2003

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